I literally just finished putting together sets from my 2010 Topps Update jumbo case. Everyone said you'd 5-6 base sets and that was exactly right. I was 16 cards short of the sixth base set, I'll pick those up on sportlots.com. The master set was a different story, I was way short of that. I had to pick up somewhere between 40 and 50 insert cards to complete that. I was able to pick all of those up on sportlots.com for just under $30.
All in all, I'd say it took me between 6 and 7 hours to put these sets together. I think the next time I buy a case like this I'll put cards in order as I open them, as lame as that sounds. I just can't stand sitting down at a table for hours on end sorting cards. Anyway, the picture below shows the aftermath of the sorting.